The film “Mistérios do Nixipae” portrays the emergence of the Nixipae drink (ayahuasca) in the worldview of the Huni Kuî people. In a hybrid language between fiction and documentary, indigenous leader Isaka Ruy guides us through a story that permeates the world of the enchanted. This short film is the result of a sociocultural audiovisual training project in the Katukina-kaxinawa Indigenous Territory, in the Brazilian Amazon rainforest.